Trestolone (MENT / 7α-Methyl-19-Nortestosterone)
Trestolone, also known as MENT, is a synthetic anabolic-androgenic steroid derived from 19-nortestosterone. It was originally researched as a potential male contraceptive due to its strong androgenic activity and unique chemical structure.
Unlike testosterone, trestolone cannot bind to 5α-reductase and therefore does not convert to dihydrotestosterone (DHT). This property made it a promising androgen substitute in contraceptive research.
Potency & Mechanism
Trestolone contains a 7α-methyl group that blocks DHT conversion while still allowing aromatization and androgenic activity. This allows it to function similarly to testosterone despite being a 19-nor derivative.
Theoretical ratios suggest trestolone may be up to 23× more anabolic and 6.5× more androgenic than testosterone. A 1992 animal study reported anabolic effects approximately 10× greater than testosterone, with significantly stronger HPTA suppression.
Key Characteristics
- Extremely anabolic compound
- Rapid effects on strength and muscle mass
- Does not convert to DHT
- Does not bind to SHBG
- Minimal interaction with progesterone receptors
- No significant increases in hematocrit reported
- Increased appetite
Medical Research Applications
- Male hormonal contraception
- Hypogonadism
- Cachexia and sarcopenia
- Bone density loss
- Prostate-related conditions
Warning: Trestolone is not approved for general medical use. Minors should not use this compound due to the risk of accelerated and abnormal sexual development.
